abstract |
The present invention relates to substituted 4-pyridones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing them and their methods of use as agents for the treatment and / or prevention of diseases. pulmonary, gastrointestinal and genitourinary, inflammatory diseases of the skin and eyes and other autoimmune and allergic disorders, rejection of allografts and oncological diseases. |