| abstract |
This invention generally relates to therapeutic compounds and methods useful for treating diseases in humans. More specifically, the present invention relates to methods and reagents useful for treating humans suffering from metabolic diseases. More specifically, the present invention relates to covalent insulin conjugates and analogs with nucleic acid derivatives that are capable of modulating gene expression. In addition, this invention relates to the use of said conjugated insulins for the treatment of metabolic diseases, including diabetes mellitus. |