| abstract |
The present invention relates to salts and hydrates of 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- (cis-4- {N - [(morf-1 -olin-4-yl)) carbonyl] -N-methyl-amino} -cyclohexan-1-yloxy) -7-methoxy-quinazoline of the formula (I), wherein x means Q x H2O, x HCl or (x 0.5 HCl / x 1, 5 H2O), which shows valuable pharmacological properties, in particular an inhibitory effect on signal transduction mediated by tyrosine kinases, to a procedure for stereoselective preparation of this compound, in particular for inhalation of suitable pharmaceutical formulations and their use for the treatment of diseases, in particular tumor diseases, of benign prostatic hyperplasia, as well as diseases of the lung and respiratory tract. |