| abstract |
The invention is directed to thienopyrimidine and thienopyridine compounds of Formula I and Formula II: where R1, R3, B, Z, Q,, and X are as defined herein, to the use of said compounds as modulators of the protein tyrosine kinase, particularly FLT3 inhibitors, to the use of said compounds to reduce or inhibit the kinase activity of FLT3 in a cell or in a subject, and to the use of said compounds to prevent or treat in a subject, a proliferative disorder of cells and / or disorders related to FLT3. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating disorders such as cancers and other proliferative cell disorders. |