| abstract |
The invention is directed to aminoquinoline and aminoquinazoline compounds of Formula I: in which R1, R2, R3, B, Z, Q, p, q and X are as defined herein, the use of said compounds as protein modulators tyrosine kinase, particularly inhibitors of FLT3 and / or TrKB, to the use of said compounds to reduce and inhibit the kinase activity of FLT3 and / or TrKB in a cell or a subject, and to the use of said compounds to prevent or treat in a subject , a disorder and / or proliferative disorders of cells related to FLT3 and / or TrKB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating disorders such as cancers and other proliferative cell disorders. |