| abstract |
Controlled release formulations with a coated core, this drug composition comprising and hydro-swellable composition, each occupying separate regions within the core. The medicament comprising PDE4D inhibitor, or a pharmaceutically acceptable salt thereof, preferably (R) -2- (4 - ((2- (benzo (1,3) dioxol-5-yloxy) -pyridine-3-carbonyl) - amino) -methyl) -3-fluoro-phenoxyl) -propionic, or 2- (4-fluorophenoxy) -N- (4- (1-hydroxy-1-methyl-ethyl) -benzyl) -nicotinamide, or one of the pharmaceutically acceptable salts thereof, and a medicament carrying agent The core cover is water permeable, insoluble in water and has at least one release pore. Nausea and emetic effect reducing procedures of PDE4D inhibitors, and formulations with improved PDE4D inhibitor profiles in vivo and in vitro. |