| abstract |
A compound of the formula: or a pharmaceutically acceptable salt, ester or ester thereof, wherein from R1 to R12 are independently hydrogen or the like; X1 and X2 are independently CH2 or the like; R13 is hydrogen or the like; or R12 and R13 taken together with three ring atoms of the quinoline ring separating said substituents form a heterocyclic ring; R14 and R14 are hydrogen or the like, or these groups taken together form a group; oxo; and the dashed line represents a single or double bond. These compounds are linked to the ORL-1 receptor and especially are antagonists of said receptor. |