| abstract |
Compounds of the general formula R is phenyl, pyridin-2-yl, -C (O) -morpholinyl, .C (O) -NR! 2, - (CH2) n- NR! 2 or - (CH2) n-O-lower alkyl, and R, may be hydrogen or lower alkyl; and to pharmaceutically acceptable addition salts. They can be used in the control or prevention of diseases based on the modulation of the adenosine system, such as Alzheimer's, Parkinson's, Huntington's disease, neuroprotection, schizophrenia, anxiety, pain, respiratory deficits, depression, drug addiction, such as amphetamine, cocaine, opioids, ethanol, nicotine, cannabinoids, against asthma, allergic responses, hypoxia, ischemia, seizures, substance abuse. They can be useful as sedatives, muscle relaxants, antipsychotics, antiepileptics, anticonvulsants and cardioprotective agents for disorders such as coronary artery disease and heart failure. cariac |