| abstract |
The invention relates to sorbitol dehydrogenase inhibitor compounds of formula I, wherein Rl, R2 and R3 are as defined in the specification. It also relates to pharmaceutical compositions containing those compounds and to methods of treating or preventing diabetic complications, particularly diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy, and diabetic cardiomyopathy, by administering such compounds to a mammal suffering from diabetes and which, therefore, can develop such complications. This invention comprises pharmaceutical compositions comprising a combination of a compound of formula 1 of this invention with an aldose reductase inhibitor and methods of treatment or prevention of diabetic complications with such compositions. It also includes pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor, and methods of treating cardiomyopathies and other heart related problems with such compositions. This invention also relates to certain intermediates used in the synthesis of the compounds of formula I and to procedures for preparing those intermediates. |