| abstract |
Pharmaceutical compositions comprising one or more orally administrable dosage units or dosage forms are provided, each comprising particulate celecoxib in an amount of from about 10 to about 1000 mg in intimate mixture with one or more pharmaceutically acceptable excipients. The compositions are useful in the treatment or prophylaxis of cyclooxygenase-2 mediated conditions and disorders. Celecoxib compounds (formula I) are useful in the treatment of inflammation and inflammation-related disorders associated with rheumatoid arthritis and osteoarthritis. Also these compositions are useful in neoplasms with metastasis, ophthalmolgenic disorders such as rejection of graft corneal, gastric ulcer, disorders of the female reproductive system, unstable angina, etc. Also in other conditions such as lupus erythematosus, pain treatment, low back pain, hepatitis, psoriasis, gingivitis, nephritis, Alzheimer's, senile dementia, etc. The process for preparing one of the pharmaceutical forms is described in figure I |