| abstract |
The invention constitutes a novel series of cyclic amino acids (1-aminomethyl-cyclopentyl-acetic acids and 1-aminomethyl cyclopentyl-acetic derivatives) useful for the treatment of: epilepsy, fainting, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders (irritable bowel syndrome (IBS) and inflammation, (especially arthritis). It also includes pharmaceutical composition containing a compound of the invention, preparing the compounds and intermediates useful in the preparation of the final compounds. They are compounds of formula l ll ( such as: (+ -) - (trans) - (1-aminomethyl-3,4-dimethyl-cyclopentyl) -hydrochloride acetic acid) or a pharmaceutically acceptable salt obtained from them characterized in that: R is H or a lower alkyl; R1 to R14 are independently selected from H, straight or branched alkyl, phenyl benzyl, F, Cl, Br, hydroxy, hydroxymethyl, amino, aminomethyl, tr ifluoromethyl, CO2H, etc. A pharmaceutical composition characterized by comprising a therapeutically effective amount of a compound and a pharmaceutically acceptable carrier. |