| abstract |
The present invention relates to the derivatives of benzoic acid phenylamino, benzamides and benzyl alcohol of the formula (I), where: R1 is H, hydroxy, alkyl, alkoxy, halo, trifluoromethyl or CN; R2 is H; R3, R4 and R5 are independently H, hydroxy, halo, trifluoromethyl, alkyl, alkoxy, nitro, CN; Z is COOH, tetrazolyl, CONH2, CONHNH2, or CH2OH; and the pharmaceutically acceptable salts thereof. Likewise, the invention relates to a process for their preparation, to pharmaceutical compositions containing them and to their use in therapy. Such compounds are MEK inhibitors and as such are effective for the treatment of cancer and other proliferative diseases. Non-limiting Ex: 2- (4-Bromo-2-methyl-phenylamino) -4-fluoro-benzoic acid. |