| abstract |
Process for preparing: a compound of formula (3) (see figure 1) and the pharmaceutically acceptable salts or derivatives thereof in which R1 is vinyl or ethyl; R3 and R4 is an azabicyclic ring system or R5 and R6, together with the carbon atom to which they are attached, form an azabicyclic ring system. The process is characterized by reacting a compound of those represented in figure 2 with an acyl isocyanate. The azabicyclic ring is for example selected from azabicyclo [2.2.2] octyl, azabicyclo [2.2.1] heptyl, azabicyclo [3.2.1] octyl, among others. Non-limiting example: 14 (1-aza-bicyclo- [2.2.2] octane-4-carbonyl) carbamic acid mutilin ester. These compounds are useful in the prevention and treatment of microbial infections. |