http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE39888-E
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_299cff96bb72ae26b6cfe2d849f81bc9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 1998-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acfdd528e02901c937c8eb6f378b78de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c523e96af869992313db6dc353aa579c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0660364f5a86d325343f077419bd7b2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c21d7b211b95d5c740d5d6dba73804d0 |
| publicationDate | 2007-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-RE39888-E |
| titleOfInvention | Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride |
| abstract | The process for obtaining quinapril hydrochloride (I) comprises the stages of: a) hydrogenolysis of the benzyl ester of quinapril (II) by treatment in an alcoholic solvent, with concentrated hydrochloric acid or a solution of hydrogen chloride in isopropanol, and hydrogenation; b) removal of the solvent; c) addition of toluene to precipitate the quinapril hydrochloride as a toluene solvate; d) treatment of said solvate with a Class 3 solvent which forms a solvate of quinapril hydrochloride from which it can be removed by drying without degrading; and e) drying of the solvate from step d) to yield quinapril hydrochloride (I), an antihypertensive agent. |
| priorityDate | 1997-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.