| abstract |
Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: n n nwhereinn R 1 represents farnesyl, geranyl or geranyl-geranyl; Z represents C—R 6 or N; R 2 represents H, CN, the groups COOR 7 , SO 3 R 7 , CONR 7 R 8 and SO 2 NR 7 R 7 , wherein R 7 and R 8 are each independently hydrogen, alkyl, alkenyl, and the groups COOM and SO 3 M, wherein M is a cation; R 3 , R 4 , R 5 and R 6 are each independently hydrogen, carboxyl, alkyl, alkenyl, aminoalkyl, nitroalkyl, nitro, halo, amino, mono- or di-alkylamino, mercapto, mercaptoalkyl, azido, or thiocyanato; X represents O, S, SO, SO 2 , NH or Se; and the quaternary ammonium salts and N-oxides of the compounds of formula I wherein Z is N. |