| abstract |
A compound of formula (I) n n nwhereinn R 1 is a C 1-6 straight or branched chain alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 3-6 cycloalkyl group or a C 3-6 cycloalkylC 1-6 alkyl group, each optionally substituted by one to three groups independently selected from: —CN; —NO 2 ; a group —COR 2 wherein R 2 is hydrogen, C 1-6 alkyl, —OR 3 wherein R 3 is hydrogen or C 1-6 alkyl or NR 4 R 5 wherein R 4 and R 5 are independently selected from hydrogen or C 1-6 alkyl; a group —S(O) m R 6 wherein m is 0, 1 or 2, R 6 is hydrogen, C 1-6 alkyl, hydroxy or NR 7 R 8 wherein R 7 and R 8 are independently hydrogen or C 1-6 alkyl; a group PO(OR 9 ) 2 wherein R 9 is hydrogen or C 1-6 alkyl; a group NR 10 R 11 wherein R 10 and R 11 are independently selected from hydrogen, C 1-6 alkyl, —COR 12 wherein R 12 is hydrogen or C 1-6 alkyl, or —S(O) m′ R 13 wherein m′ is 0, 1 or 2 and R 13 is hydrogen or C 1-6 alkyl; halo; or a group —OR 14 wherein R 14 is hydrogen, C 1-6 alkyl optionally substituted by one to three halo atoms, C 6-10 aryl or —COR 15 wherein R 15 is hydrogen or C 1-6 alkyl; p is 2 or 3, q is 1 or 2 and n is 0 or 1 and all salts, esters, amides and physiologically acceptable prodrugs thereof; pharmaceutical uses and formulations therefor; and processes for their preparation are disclosed. |