| abstract |
A piperidine compound of the formula (I): n wherein A is a fused aromatic ring; R is hydrogen, chloro or methoxy; X is (CH 2 ) n , which may be substituted, in which n is 0 or an integer of 1 to 10, —CH≡CH—, —C≡C—, —O—, —S—, —NH—, —N(COCH 3 )—, —N(COOC 2 H 5 )—, —N(CHO)—, —N(CH 3 )—, —CO—, —SO—, or —SO 2 —; Y is —CH≡CH—, —CH 2 CH 2 —, —CH 2 CO—, —O—, —S—, —NH—, —OCH 2 —, —SCH 2 —, —NHCH 2 —, —CH(OH)CH 2 — or —CH(OH)CH(OH)—; and Q is substituted or unsubstituted n-hexyl, carboxypropyl, ethoxycarbonylpropyl, cyanopropyl, cyclohexyl, phenyl, indanyl, naphthyl, tetrahydronaphthyl, benzocycloheptyl, piperidinyl, tetrahydroisoquinolinyl, indolyl, pyrolyl, furyl, thienyl, thiazolyl, oxazolyl or N-methylpyrolyl, wherein any one or more of the —(CH 2 )-groups of the hexyl, carboxypropyl, ethoxycarbonylpropyl and cyanopropyl groups may be replaced by —CH≡CH—, —C≡C—, —O—, —S—, —NH—, —N(COCH 3 ), —N(COC 2 H 5 )—, —N(CHO)—, —N(CH 3 ), —CO—, —SO— or —SO 2 —, and wherein one or more of the —(CH 2 )-groups in X and Q may be substituted by —(CH 2 ) 4 — or —(CH 2 ) 5 — thereby forming a ring structure. |