| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_255ea743d5f234e70fb6a537572bcaa2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22c01b99379714d93cb22d7748329aa9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5fe399c3258493c630bfc0714d49e564 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G2230-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09D175-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G71-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C275-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C247-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-34 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09D175-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G71-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C247-04 |
| filingDate |
2014-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f6e035e3f8625d91301330f0936bc55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e460165f4be5316f0584166045b79d43 |
| publicationDate |
2018-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9988492-B2 |
| titleOfInvention |
Methods for post-fabrication functionalization of poly(ester ureas) |
| abstract |
Amino acid-based poly(ester urea)s (PEU) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of PEUs carrying pendent “clickable” groups on modified tyrosine amino acids. The pendent species include alkyne, azide, alkene, tyrosine-phenol, and ketone groups. PEUs with M w exceeding 100k Da were obtained via interfacial polycondensation methods and the concentration of pendent groups was varied by copolymerization. The incorporation of derivatizable functionalities is demonstrated using 1 H NMR and UV-Vis spectroscopy methods. Electrospinning was used to fabricate PEU nanofibers with a diameters ranging from 350 nm to 500 nm. The nanofiber matricies possess mechanical strengths suitable for tissue engineering (Young's modulus: 300±45 MPa; tensile stress: 8.5±1.2 MPa). A series of bioactive peptides and fluorescent molecules were conjugated to the surface of the nanofibers following electrospinning using bio-orthogonal reactions in aqueous media. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020226646-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019104163-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020368164-A1 |
| priorityDate |
2013-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |