| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae537f01102c5d7a9a8803b39c26dd75 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54306
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N27-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6825
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-48721 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-487 |
| filingDate |
2016-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9dd8481c4f778a86b1726ed3f96859e |
| publicationDate |
2018-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9983191-B2 |
| titleOfInvention |
Nanopore detection of small molecules through competition assays |
| abstract |
Disclosed herein are methods and compositions for detection of target small molecules in a mixed sample by performing a competition assay between the target and a surrogate and subsequently detecting the complex types in a nanopore device. Disclosed herein are competition assays for detection of small molecules using a nanopore. Target molecules of a sufficient size (>20 kDa) when passed through a solid-state nanopore cause a change in the current impedance, translocation time, or other measurable parameter. In the event the target molecule is not sufficiently big, and thus does not cause a noticeable change, an additional molecule/reagent can be used to aid in detection. This detection reagent would bind to the small molecule or to the “capture ligand-molecule complex” (e.g. peptide detection is aided by a monoclonal antibody (mAb) that recognizes a peptide/aptamer complex). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10871482-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10670590-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11486873-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10837954-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016266089-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017349940-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018313814-A1 |
| priorityDate |
2015-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |