| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4047b0f33ae605e46e352cfbf9da7588 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-14 |
| filingDate |
2013-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ca9ffb6925e484892bff36d40653bfb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d40cf0957c09f689044b38ca7055f6e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ee98acf336503c09efde848af441686
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45d0cf87e42c1caf0a1719e7185102cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a0c8cfba2b45ba8ed33490afd18642b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_661a524a0a40fdd6156490f9b743b209
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fbbaf6b3d8b71455ba7845f98f6725d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bb4a6a9a4891e915cbc50ca10c2e234 |
| publicationDate |
2018-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9956304-B2 |
| titleOfInvention |
Contrast agents, methods for preparing contrast agents, and methods of imaging |
| abstract |
Provided is a protein contrast agent for enhancing an MRI image and comprising a polypeptide having a conformation presenting at least five oxygen atoms positioned to chelate at least one paramagnetic metal ion such as Gd 3+ , each oxygen atom being between about 2 angstrom units and about 5 angstrom units from the metal ion; the metal ion has at least one water molecule electrostatically interacting a distance of less than about 10 angstrom units a target-specific moiety conjugated thereto, at least one polyethylene glycol molecule, and a paramagnetic metal ion. Also provided is a method of obtaining an enhanced MRI image using the protein contrast agent to a T2/T1 or T1/T2 intensity ratio of the MRI image; and (d) obtaining an image of the T2/T1 or T1/T2 intensity ratio. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018280544-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10814021-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022040649-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11426471-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11419954-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10814020-B2 |
| priorityDate |
2012-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |