| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20d3042eb4ea7c9afd525aa89373349d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2539-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0068
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L39-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09D133-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L33-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L33-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L39-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L33-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L33-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L39-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L39-06 |
| filingDate |
2014-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53751c394a0338da10e5c82d4ef694ef |
| publicationDate |
2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9951308-B2 |
| titleOfInvention |
Temperature-responsive cell culture substrate and method for producing same |
| abstract |
Provided is a cell culture substrate, in which polymer (B) having a lower critical solution temperature contained in the substrate is a copolymer of a monomer (a) that becomes a hydrophobic polymer in homopolymerization and a monomer (b, c or d) that becomes a hydrophilic polymer in homopolymerization, which is uncrosslinked, and the lower critical solution temperature of the obtained copolymer (B) can be controlled widely by the types and ratio of the two monomers, to easily detach the cultured cells from the culture substrate surface rapidly without using protein hydrolase and collect the cells without damage. This cell culture substrate contains a polymer (A) of a (meth)acrylic acid ester monomer (a), one or more types of inorganic materials (C) selected from a water-swellable clay mineral and silica, and a polymer (B) having a lower critical solution temperature and including a monomer (a) and a monomer (b, c or d). |
| priorityDate |
2013-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |