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filingDate 2016-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2018-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9938553-B2
titleOfInvention Methods and devices for nucleic acid synthesis
abstract Disclosed are devices and methods to synthesize polynucleotides and libraries of polynucleotides such as libraries of oligonucleotides. In exemplary embodiments, the device includes a support having a plurality of features. Each feature contains a plurality of oligonucleotides. Within each feature, each of the plurality of oligonucleotides includes an identical predetermined subunit sequence of X nucleosides and a degenerate sequence of Y nucleosides. A predetermined combination of a subset of the features can be used to produce a polynucleotide having a predetermined sequence of Z nucleosides.
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