http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9925213-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e96496a9949403e2af2ca913e65bfec http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c9542186133097bd6bbb7d92393090 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0082 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L77-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-785 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-785 |
| filingDate | 2015-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8dd9d8f09fd5e208babc288f10c5f48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fcf159f946c5df75d334f01e135721f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21406d37828995e69c1113ab4d1928a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b55f6e8248692a6469c87ecd49605cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bc9de7eaaf882b906985a68d2dd32a5 |
| publicationDate | 2018-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9925213-B2 |
| titleOfInvention | Nylon-3 co-polymers and synthetic lung surfactant compositions containing same |
| abstract | Non-natural oligomers have recently shown promise as functional analogs of lung surfactant proteins B and C (SP-B and SP-C), two helical and amphiphilic proteins that are critical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restricted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-B mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, are prepared by ring-opening polymerization of β-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B. Attachment of an N-terminal octadecanoyl unit to the nylon-3 copolymers affords further improvements by reducing the percent surface area compression to reach low minimum surface tension. |
| priorityDate | 2010-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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