| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e757fd4fedc4fe825bb81b1b466a0947
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37b416a8c0d2b0f1c3d6026d932027af |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G64-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G63-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G64-183
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G63-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G64-025 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G64-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G64-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 |
| filingDate |
2016-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_584d98107282ff0d0aa35208e4177f26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0af6615b12fa2bddc3eafaa353c45a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2386849ca0e84b1200eec43c4944c74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e914d4c2fd24e1a3d0856b49bda0f73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e693aa79a6794262ece432f5a54fa74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb356ae7571a3d11f5c7d775777405f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9dfd0390e7f09e4a1ccf12905193600
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9eb9a16df038825fd2a93adf1e88415 |
| publicationDate |
2018-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9901649-B2 |
| titleOfInvention |
Block copolymers for therapeutic drug delivery |
| abstract |
Amphiphilic block copolymers (BCPs) were prepared comprising a poly(ethylene oxide) block and a biodegradable polycarbonate block functionalized with disulfide groups and carboxylic acid groups. The BCPs form self-assembled micellar particles in aqueous solution that can be loaded with hydrophobic drugs for therapeutic drug delivery. The loaded particles have small particle sizes (<100 nm), narrow particle size distributions, and high drug loading capacity (up to about 50 wt %) based on total dry weight of the loaded particles. Particles loaded with DOX released the DOX in response to changes in pH and glutathione (GSH) redox chemistry. The loaded particles efficiently delivered and released DOX within tumor cells, effectively suppressing growth of the tumor cells at a similar or even lower drug concentration than free DOX. Blank particles containing no DOX did not induce cytotoxicity to cells. |
| priorityDate |
2016-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |