| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3155069b833b184bcd4ad12f7100dd4c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T2207-30024
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T2207-10064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T7-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G02B21-16 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6456
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G02B21-0076
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T3-4053 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G02B21-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06T7-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06K9-62 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06T3-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G02B21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate |
2014-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0235a4c9404a9cda8ee711d1b77960d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3637ef6b6fd5207c7664badf6c8ee4d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbe4cb409019fba012a7c84b5e4801bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_336a224c805ecf8a0bd23bf1188c45e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc75b9516d385a4c4cb950dc15c66649 |
| publicationDate |
2018-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9881355-B2 |
| titleOfInvention |
Three-dimensional single-molecule fluorescence imaging beyond the diffraction limit using a double-helix point spread function |
| abstract |
Embodiments of the present invention can resolve molecules beyond the optical diffraction limit in three dimensions. A double-helix point spread function can be used to in conjunction with a microscope to provide dual-lobed images of a molecule. Based on the rotation of the dual-lobed image, the axial position of the molecule can be estimated or determined. In some embodiments, the angular rotation of the dual-lobed imaged can be determined using a centroid fit calculation or by finding the midpoints of the centers of the two lobes. Regardless of the technique, the correspondence between the rotation and axial position can be utilized. A double-helix point spread function can also be used to determine the lateral positions of molecules and hence their three-dimensional location. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10791318-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020160893-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10317597-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108956575-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016301915-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10638112-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108956575-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-D879800-S
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-D860229-S
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016062100-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10187626-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3690510-A1 |
| priorityDate |
2008-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |