| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8adaddc602ad7cb7f9e2d550681bb36d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2563-125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2565-133
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2565-1015
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2525-101 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6818
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6806
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6874 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2016-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d0cf75e0b3ec0cc76b5ce2a0b40b6ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94bcba3f8c43e9b9a84108c4c9a99aac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bef9cef8946b124f58226a2a12a782c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_895aa4633a691a3e39df59d2027ab3b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d08701ffe7405535db7b175cf84d9352
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4a2a32e6a9106ad82ccee0a29685a1e |
| publicationDate |
2018-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9862998-B2 |
| titleOfInvention |
Conformational probes and methods for sequencing nucleic acids |
| abstract |
This disclosure provides a method of determining a sequence of nucleotides for a nucleic acid template. The method can include the steps of contacting the nucleic acid template with a conformationally labeled polymerase and at least four different nucleotide species under conditions wherein the conformationally labeled polymerase catalyzes sequential addition of the nucleotide species to form a nucleic acid complement of the nucleic acid template, wherein the sequential addition of each different nucleotide species produces a conformational signal change from the conformationally labeled polymerase and wherein the rate or time duration for the conformational signal change is distinguishable for each different nucleotide species; detecting a series of changes in the signal from the conformationally labeled polymerase under the conditions; and determining the rates or time durations for the changes in the signal, thereby determining the sequence of nucleotides for the nucleic acid template. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10954551-B2 |
| priorityDate |
2010-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |