http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9801961-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0459 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate | 2015-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d361c8cd448909c6953bdb08cd51e78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94db340f489be26a21d28a776465b728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1587176c842f346fcdb10c856e049df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_520f33558afc03a605e7c82123805a40 |
| publicationDate | 2017-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9801961-B2 |
| titleOfInvention | 2-phenylimidazo[1,2-a]pyrimidines as imaging agents |
| abstract | The present invention relates to compounds of general formula n nwhereinn R 1 is (a) phenyl, optionally substituted by one or two substituents selected from 3 H, halogen, lower alkyl, di-methyl-amino, NHC(O)-lower alkyl, C(O)O-lower alkyl, lower alkoxy, OC( 3 H) 3 , O 11 CH 3 , OCH 2 CH 2 18 F, lower alkoxy substituted by halogen, hydroxy, lower alkyl substituted by hydroxy, S-lower alkyl, (b) heterocyclyl group, (c) benzo[d][1,3]dioxol-5-yl, (d) 2,3-dihydrobenzo[b][1,4]dioxin-6-yl, (e) indolin-2-one, or (f) heteroaryl, selected from the group consisting of thiophenyl, benzofuranyl, benzothiophenyl, pyrazinyl, and benzothiazolyl; R 2 is hydrogen, lower alkyl or lower alkyl substituted by halogen; R 3 is lower alkyl, C( 3 H) 3 , 11 CH 3 , lower alkyl substituted by halogen, —(CH 2 ) 2 —O-lower alkyl substituted by halogen or cycloalkyl; or R 2 and R 3 form together with the N-atom to which they are attach a ring containing —CH 2 CH 2 CHRCH 2 CH 2 —, —CH 2 CH 2 CHRCH 2 —, —CH 2 CHRCH 2 —, —CH 2 CH 2 —NR—CH 2 CH 2 —, —CH 2 CH 2 —O—CH 2 CH 2 —, or, nn nR is hydrogen, halogen, lower alkyl substituted by halogen or lower alkoxy;n or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. nn The compounds are suitable as imaging tool, which will improve diagnosis by identifying potential patients with excess of tau aggregates in the brain, which may be likely to develop Alzheimer's disease. |
| priorityDate | 2013-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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