http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9790545-B2
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d3467323b4f85c099586aa9f5d9973ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbe675b46d686407d64e31a937562663 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7a39744c21a453d217de1f61d7c1b79a |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-142 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6837 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
filingDate | 2013-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eeae324515e6087f09f99b385317b4a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f845ccec1d7827b5f88c22aec5dfe58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b48307a202a1d8373fa1c82c5d8f3a0 |
publicationDate | 2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-9790545-B2 |
titleOfInvention | Method for determining the neurodevelopmental toxicity of a compound in vitro |
abstract | This invention is in the field of medical molecular diagnostics. It provides methods and means for the in vitro detection of the neurodevelopmental toxicity of a compound by determining the gene expression of a limited number of genes. More in particular, it relates to a method for determining the likelihood that a compound is neurodevelopmental toxic, comprising the steps of: providing embryonic stem cells, allowing the stem cells to form embryoid bodies, allowing the embryoid bodies to differentiate into neural cells, in the presence of said compound, thereby creating a neural differentiation culture, extracting total RNA from the cells in said neural differentiation culture, determining the expression levels of genes Hoxb6, Nrk, 1700011H14Rik and Tph1, comparing the expression levels with a predetermined reference value and determining the increase or decrease of the expression level relative to the reference value, wherein a relative increase or decrease in expression value of more than 20% indicates that a compound is neurodevelopmental toxic. |
priorityDate | 2012-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 839.