http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9782401-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72046362a91a0f0277abe5495e47790f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-24 |
| filingDate | 2016-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3250abf9971c9c7ee4d75bbccab73f53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61b70f42f3f27edeeed1fc68837e58e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f1177a5d1f9ebd9008ac81498095351 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3871ac0d14d9bd6cd1f62501ee15361e |
| publicationDate | 2017-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9782401-B1 |
| titleOfInvention | Method of isolating phenanthroindolizidine alkaloids from Tylophora atrofolliculata with HIF-1 inhibitory activity, compositions comprising them and their use |
| abstract | A method of isolating at least one phenanthroindolizidine alkaloid, in particular with HIF-1 inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about 22 phenanthroindolizidine alkaloids, including at least 11 new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional HIF-1 inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata . A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid to the subject. |
| priorityDate | 2016-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 138.