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filingDate 2014-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2017-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2017-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9777113-B2
titleOfInvention Production method of medical polyoxypropylene polymer and production method of medical polyoxypropylene/polyoxyethylene block copolymer
abstract A method of producing a medical polyoxypropylene polymer and a polyoxypropylene/polyoxyethylene block copolymer including (A) adding to a polyoxypropylene polymer which is obtained by ring-opening polymerization of propylene oxide to a starting substance having an active hydrogen reacting with the propylene oxide and contains allyl ether as an impurity, a tertiary alkoxide of alkali metal in an excess amount based on a molar number of the active hydrogen of the starting substance and heat treating at 115° C. or less to isomerize the allyl ether to propenyl ether; and (B) adding a mineral acid to the product obtained in step (A) to adjust pH to 4 or less and treating at 70° C. or less to hydrolyze the propenyl ether. Also disclosed is a method of producing a medical polyoxypropylene/polyoxyethylene block copolymer which includes performing ring-opening polymerization of ethylene oxide to the polyoxypropylene polymer obtained above.
priorityDate 2013-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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