| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_becde6aa3035dd933425357bcabe9827 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2878
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2887
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 |
| filingDate |
2015-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87f767b758a195a450170b25bce43472
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4067f79386d53b8c152fa02bef8df789
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50b5110c66f934517116a79440d2520b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80602c61b1ffee0f86afdaa4d2f48241
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e91ae3cd7e64bce265f9ddaef7bac2b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b45c6bd9691ae3b62251498286d5d62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0e57e54f9abbc84cb297bac4fa3e4ca |
| publicationDate |
2017-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9777073-B2 |
| titleOfInvention |
Construction and application of bispecific antibody EpCAM×CD3 |
| abstract |
The present invention provides a bispecific antibody. The bispecific antibody provided by the present invention comprises a single-chain unit and a monovalent unit, wherein the single-chain unit has a specific binding capability against surface antigen CD3 of an immune cell; the monovalent unit has a specific binding capability against the surface antigen EpCAM of a tumor cell; the single-chain unit comprises a single-chain variable fragment ScFv fused with an Fc fragment; and the monovalent unit comprises a light chain and heavy chain pair. The present invention also provides a preparation method of the bispecific antibody and pharmaceutical use of these antibodies. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11434291-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10118964-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020252095-A1 |
| priorityDate |
2014-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |