| abstract |
Disclosed are compounds of formula (I); or a pharmaceutically acceptable salt thereof; wherein Y, R a , R a′ , R c , R f , X 2 , R d , R d′ , R e , R e′ , m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders. |