| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-61 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 |
| filingDate |
2013-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8bdb6f750c2825446a99edaaa185033
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b4c3c7996bbd97e205cbb80fb988a5b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0aa48f7e1e65d7b8285f79bb90ed785d |
| publicationDate |
2017-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9695133-B2 |
| titleOfInvention |
Quinazolinone-based oncogenic-RAS-selective lethal compounds and their use |
| abstract |
The present invention provides, inter alia, compounds having the structure (1) compositions containing such compounds are also provided. Methods for using such compounds or compositions for treating or ameliorating the effects of a cancer having a cell that harbors an oncogenic RAS mutation, for modulating a lipoxygenase in a ferroptosis cell death pathway, and for depleting reduced glutathione (GSH) in a cell harboring an oncogenic RAS mutation are further provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11541116-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11040964-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021127217-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019241746-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11098040-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9938245-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019241730-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016332974-A1 |
| priorityDate |
2012-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |