| abstract |
The present invention relates to tetrahydro-tetrazolo[1,5-a]pyrazine compounds of formula (I), wherein R 1 denotes —R 3 , —CH 2 —R 3 or —CO—R 3 ; R 2 denotes Ar 2 , Hetar 2 or C 3-7 -cycloalkyl; and R 3 denotes Ar 3 , Hetar 3 or C 3-7 -cycloalkyl. These compounds are useful for inhibiting the retinoid-related orphan receptor γ (ROR γ, ROR-gamma) and for the prevention and/or treatment of medical conditions affected by ROR γ activity such as rheumatoid arthritis, multiple sclerosis, psoriasis, ulcerative colitis, asthma, autoimmune hepatitis or type 1 and type 2 diabetes. |