| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114e4423ec77cbc8dab9d0a98909704e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 |
| filingDate |
2015-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f71ca8079c7f993c7097661824ed72d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6b21f3d5c2b19f517ce8b97e9829708
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a1a68bcf11e0051a9ce813abd5eedc9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6127a3bf7a24be01d9bad19d5d7c4ed1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_246247fe8c8ac59c1e7c9024027102ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc68f0feb8a9cb9c2b1a2d64595a75ab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66d09b4fdad54f871977c789cbfc513c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56e5467a6191533e464d43870f2350ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a91830d8be8e77fc025ae438af44ad05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2681a68b86dc1c8eb9c1958a5aced2b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a32e4bd6bf45b3374246cf56149e31ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_759ddf9f592cd57d336f5af95d2863a6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88ddd7b2b7a4e4b7f38f977dd6180e13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13f2185af98f197faf7abeb5d63f6060 |
| publicationDate |
2017-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9687480-B2 |
| titleOfInvention |
Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl)-pyrrolidine as inhibitors of collagen induced platelet activation and adhesion |
| abstract |
Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion. The present invention provides chiral (2S)-1-(4-methylphenylmethyl)-5-oxo-(3S)-{N-[(3-t-butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4-methylphenylmethyl)-5-oxo-(3R)-{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p-methylphenylmethyl)1pyroglutamate in good chiral purity. |
| priorityDate |
2011-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |