http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9670197-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2016-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36fca7ff6013cec98573e9f62a1d1ff7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d239a28f021cfa94a6f3c343c8aebcec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3820cfb0f2f03b0c5314e53f37bad923 |
| publicationDate | 2017-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9670197-B2 |
| titleOfInvention | Small molecule modifiers of the Hec1-Nek2 interaction in G2/M |
| abstract | Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: n n n n n n n n n n In Formula 1, Z is —CO—, —SO—, or —SO 2 —; Ar is phenyl, heteroaryl, or heterocycloalkyl; Het is heteroaryl; R is R″, X, or NR 1 R 2 ; R′ is R 3 , or OR 3 ; R″ is R 4 , or OR 4 ; R 1 and R 2 are each independently H, alkyl, or acyl; R 3 is H, heteroaryl, or alkyl; R 4 is H, heteroaryl, or C n H 2n+1 (n>2); and X is F, Br, I, CN, or NO 2 . In some embodiments, compounds having a molecular structure according to Formula 1 have the property of inhibiting a growth of a cell line selected from HeLa and MB468 with a sub-micromolar IC 50 . |
| priorityDate | 2013-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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