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filingDate 2014-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2017-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b20c8828f1dffe4a814d832759cbe8e1
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publicationDate 2017-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9669007-B2
titleOfInvention Method for obtaining a stable gel of hyaluronic acid and of a free form of vitamin C and/or a salt thereof
abstract The invention relates to a process for producing an aqueous gel comprising hyaluronic acid, vitamin C, and a stabilizing agent selected from the metabisulfites. According to the invention, such a process comprises the steps of a) preparing a mixture comprising crosslinked or non-crosslinked hyaluronic acid and/or a salt thereof with a molar mass of between 1000 Da and 10 MDa, from 0.1 to 20.0% by weight of vitamin C in its acid form, or its equivalent in ascorbate derived from a vitamin C salt, from 0.01 to 1.00% by weight of a stabilizing agent selected from the metabisulfites, and an aqueous solution added so that the hyaluronic acid content is between 0.01 and 100 mg/ml, so as to form a hydrogel, and b) degassing the mixture before the hydrogel being formed is completely swollen.
priorityDate 2013-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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