| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d36a5393ba2d34a292205901b92681e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1272
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C43-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-46 |
| filingDate |
2016-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_541f549dea5325b11bd2f19eb9a18027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e787b5dbefab2846f1cab959086e2ce5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b272b77bd08f89ed216e383eb365045
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c89bfa63f2f7aeb9c5d34a8788e806c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a06723f93dd8e570747d31427420429
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_182d66755832fcb67b3d177f280f43fa |
| publicationDate |
2017-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9643916-B2 |
| titleOfInvention |
Low molecular weight cationic lipids for oligonucleotide delivery |
| abstract |
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11471533-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023031855-A1 |
| priorityDate |
2010-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |