| abstract |
Embodiments of the invention relate to methods of treatment a cardiovascular disease in a patient comprising administering an effective amount of a statin or a pharmaceutically acceptable salt thereof in combination with an effective amount of a transition metal complex of a corrole, an optically active isomer thereof or a pharmaceutically acceptable salt thereof. Further embodiments refer to pharmaceutical compositions comprising a statin and a corrole. Optionally, the corrole has a structure: n nwherein;n nM is a transition metal selected from the group consisting of Mn, Fe, Ru, Co, V, Cr, and Cu and R 1 , R 2 , R 3 , X 1 , X 2 , X 3 X 4 ; E 2 , E 3 , E 17 and E 18 are each defined as in the specification. |