http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9636343-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cbffa3b81b3b862dc7220b5648f5f745 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 |
| filingDate | 2015-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4875f315414b5ee439fcf485f30996f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31da66490dd7bfdef9de7bf1714ed8c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_497bebefd3b9e47eb07bd613f6b61bad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_299b66f8965bb778caed4991acdaa8b8 |
| publicationDate | 2017-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9636343-B2 |
| titleOfInvention | Composition for preventing and treating acetaminophen inducing hepatotoxicity containing TNP(N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine) as an effective ingredient |
| abstract | The present invention relates to a composition for the prevention and treatment of liver toxicity originated from acetaminophen comprising TNP (N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine) as an active ingredient. The present inventors confirmed that TNP known as a 5-inosito pyrophosphate inhibitor suppressed apoptosis caused by acetaminophen in human embryonic stem cell-derived liver cells, mouse liver cells, and human hepatoma cell lines, up-regulated glutathione converted in liver cells, and inhibited JNK phosphorylation that is a kind of response against stress increased by acetaminophen. The inventors further confirmed that TNP had the activity of protecting liver cells from the toxicity caused by acetaminophen in an animal model. Therefore, TNP can be efficiently used as an active ingredient for a composition for the prevention and treatment of liver toxicity caused by acetaminophen. |
| priorityDate | 2015-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 123.