| abstract |
Substituted indole derivatives of formula (I) n nwherein the radicals have e.g. the following meaning:n R 1 is hydrogen, —C 1-6 -alkyl, R 2 is hydrogen, —C 1-6 -alkyl or cycloC 3-12 -alkyl; R 3 is —OR R 4 is hydrogen or halogen, R 5 is hydrogen, —C 1-6 -alkyl R 6 is hydrogen, —C 1-6 -alkyl R is hydrogen or —C 1-6 -alkyl; X is a group —C(O)CH 2 — or —CH═CH—; R 7 is hydrogenn nare potent inhibitors of Abeta peptide polymerization and can be used for the treatment of e.g. Alzheimers disease or ocular disorders. |