| abstract |
Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein i.a. Ring A is phenylene or 5- to 6-membered heteroarylene; Ring B is phenylene, 5- to 6-membered heterocycloalkylene or 5- to 6-membered heteroarylen; R 4 is absent, heteroarylene, arylene, C1-3 alkylene, or R 4 and R 3 taken together with the nitrogen to which they are bound form a 3- to 7-membered heterocycloalkyl ring; R 5 is absent, C(O)NR 51 , NR 52 or O; R 6 is C2-10 alkylene or alkenylene, wherein one or two of the carbon atoms in the alkylene chain is optionally replaced by an O, S, SO, SO 2 or NR 61 , and wherein two of the carbon atoms in the alkylene chain are optionally connected by a two or three carbon atom alkylene chain to form a 5- to 7-membered ring; R 7 is absent, NR 71 or O. The compounds are IRAK4 inhibitors useful for the treatment of inflammatory diseases. |