Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114e4423ec77cbc8dab9d0a98909704e |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-20 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-10 |
filingDate |
2014-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2017-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fde4e4a3dfcf8a77723d07aa04ab1e6d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_978b0353f63d544ee2364d71f79fc392 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60b739c10816d82beddc8802af895199 |
publicationDate |
2017-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-9617280-B2 |
titleOfInvention |
Spiro-oxazines, indolinones and preparation thereof |
abstract |
The present invention relates to novel spiro-oxazine analogues of Formula-I and Indolinone compounds of Formula-II or positional isomers, or stereoisomers, or derivatives, or pharmaceutically acceptable salt thereof. Formula-I Formula-II Further the invention provides transition-metal free multicomponent reaction (MCR) process for the preparation of said compounds of Formula-I and II using aryne precursor, N-substituted isatin and N-heteroaromatic compound as the nucleophile, under mild condition leading to formation of desired complex of spiro-oxazine analogues (I) and indolinone analogues (II) in high yield and selectivity. |
priorityDate |
2013-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |