| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c7cecac0032a0baad15c729e4c74512
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_988543aa44d954f2adf85198595ec5a6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56ff8539f4138c96b25777ecd70c4898
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee29107783095e21acac303ab5c5f3c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b69b041128b85c38a4e5233a394773f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30141580e12714e703d79f3ea3f571d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8c0982b0f02b1ed6d20a315370a3a3a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae7e78ba936231bfbe885543fd866822
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4be7a858e7d771a5dde04b23cab6e1f4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1272
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48246
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4164
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6911
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6913
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48815 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate |
2011-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c50d3dc3a8e67dad53a33a5d13193ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dd713486b3952f64e49f4c7b29fca91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca5a158d6e0818a640b60255fe422c5d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6ce86693a3b8bd0743a2759a08a4ec1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d62db698d8c33e6c7eec5098569e57d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13dfc1c4b7c4191b6b6fcb7c3eef73c2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a9515d07f2b4259b16d568aa1e27b15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fae3ceb5d739f18c5498d9362e747724 |
| publicationDate |
2017-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9616137-B2 |
| titleOfInvention |
Nanoparticle-based tumor-targeted drug delivery |
| abstract |
The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalently attached to a legumain-binding moiety. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022152939-A1 |
| priorityDate |
2010-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |