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publicationDate 2017-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9616037-B2
titleOfInvention Aryl-phenyl-sulfonamido-cycloalkyl compounds and their use
abstract The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc.
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http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID45051774
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID25097035
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID45279398
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID2909
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ4G3H4
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419546881
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID449942356
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID45278972

Total number of triples: 2184.