| abstract |
The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, n n n n n n n n n n n n where in the formula, the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q stands for a hydroxyl-group and Z stands for a hydroxyl- or oxo-group, R 1 and R 2 independently represent hydrogen atom or a straight or branched C 1-10 alkyl- or aralkyl-group, optionally substituted with —ONO 2 group, or an aralkyl- or aryl-group, which contains heteroatom, R 3 represents a straight or branched, saturated or unsaturated C 4-6 hydrocarbon group, or a C 4-10 alkylcycloalkyl- or cycloalkyl-group, or an optionally with alkyl group or halogen atom substituted phenyl-, C 7-10 alkylaryl- or hetaryl-group, Y represents (CH 2 ) n group or O atom or S atom, and where n=0-3. |