Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4572a6943c8d83a294530e4f9787f7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_057aa87bbd10d372171d6947d57d948a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_944fb57115732c5d0f48be98513f4cf8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48635c751258c12eaa300cd853e20dc3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cea57544421e14ebd0765bd9516e5c43 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4462 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4458 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4465 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-481 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4462 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4465 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4458 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26 |
filingDate |
2011-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2017-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52aec49b01b14f11a7cc9b3fb97a9363 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48b412b3783ee366f63e9b1b1b60ad80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3561e461a8c5abf5b95dbd4fb8785ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6e0e13a9f3aefc43843dd5c87c369a7 |
publicationDate |
2017-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-9566342-B2 |
titleOfInvention |
Compounds for treatment of heart failure |
abstract |
A combination of: a first tetracycline (TC) component; and a second component capable of releasing nitric oxide (NO) or a nitrate capable of mimicking NO effects in vivo (NO mimetic). The combinations of the invention advantageously act as more effective MMP modulators with selective reductions in circulating MMP-9 levels in-vivo and inhibitory effects on MMP-2 and MMP-9 levels in-vitro. The combinations of the invention also advantageously act as modulators of inflammation mediators. The co-existence of abnormalities of MMP enzymes and inflammation in many diseases make these characteristics advantageous. Therefore, the various combinations of the invention find utility in medical applications where MMPs and/or inflammation is implicated. |
priorityDate |
2010-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |