| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_816e118421e74b6d5461412f8243b606
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e75810cb7d022e16fc3e012a68ae090
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c865ac9fc1e3fc2baad0b7193a66ab85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7adbe99ca6f200fc5c00589e2e297a64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6fc40dde689dca39c97f9ab504cc415 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57426
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-9413 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-549
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-94 |
| filingDate |
2012-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbc3275da103f7a7f5eb6ff68262b643
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9da72af7a27eeecb824bc5ca23f5c34a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_405567863303beb9bf86bce519bcdc38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1cb40aee90a0a1a504b28b2ebae6f26 |
| publicationDate |
2017-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9566282-B2 |
| titleOfInvention |
Methods for identifying and validating selective anti-cancer stem cell agents |
| abstract |
Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine derivative, such as thioridazine or chlorpromazine. Optionally, the cancer is acute myeloid leukemia. Also described are methods for identifying subjects with cancer, methods for providing a prognosis for a subjects with cancer and methods for identifying subjects likely to be responsive to therapy with DR receptor antagonists. Methods for identifying cancer stem cells and chemotherapeutic compounds that are DR receptor antagonists as also provided. Also described are methods for the identification and validation of agents that target cancer stem cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10918714-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10618973-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11267870-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11332523-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11377485-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10495645-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11319567-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016274121-A1 |
| priorityDate |
2011-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |