| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b16e2ca97c9f369665427b635f1b2eb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82b18725d8f851ee4050337636ea1c9f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_758e58e8a2be75c2572bc5520cbcd32c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41ecfe3430156a85b1d11fcc2a98d056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3de3fd017961b7305682390c2b46c259 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-01 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-75 |
| filingDate |
2011-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90495c927f5bd185ad40e0b2cf2d6dfa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b84730614180cfc1f6fe88d28bb4b564
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b3e57efca8ce885f99d15bc60a0b583
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b385b137e50ea6f7baab7133ca133d9 |
| publicationDate |
2017-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9546381-B2 |
| titleOfInvention |
Use of anticoagulants in the production of recombinant proteins in the milk of transgenic animals |
| abstract |
The invention relates to the production of recombinant human fibrinogen (rhFib) in the milk of transgenic mammalian animals. This production and subsequent purification process is generally hampered by the occurrence of so-called ‘clots’ and ‘flakes’ in the milk which, in severe cases, may prevent the cow from being milked at all, resulting in a halt of lactation. These clots and flakes occur because of the expression of the fibrinogen protein, which is a factor that is normally involved in blood clotting. The invention relates to solving this milk clotting problem by treating the (lactating) animals with anticoagulants such as coumarins. A preferred anticoagulant that is used in the methods of the present invention is warfarin. |
| priorityDate |
2010-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |