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filingDate 2012-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2016-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2016-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9511123-B2
titleOfInvention Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of factor VIII
abstract The present invention relates to pharmaceutical preparations comprising Factor VIII, a sulfated glycosaminoglycan and a hyaluronidase for the non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders. The invention further relates to the combined use of a Factor VIII, a sulfated glycosaminoglycan and a hyaluronidase for the treatment and prevention of bleeding disorders, and to a method for increasing the bioavailability after non-intravenous administration of Factor VIII by co-administration of a sulfated glycosaminoglycan and a hyaluronidase.
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